[Prevalence of type-specific human papillomavirus infection among 18-45 year-old women from the general population in Liuzhou, Guangxi Zhuang Autonomous Region: a cross-sectional study].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

PubMedID: 28468064

Wu X, Zhao J, Cui XL, Li Q, Tao H, Pan QJ, Zhang X, Chen W, Li YP, Li RC, Wu T, Li MQ. [Prevalence of type-specific human papillomavirus infection among 18-45 year-old women from the general population in Liuzhou, Guangxi Zhuang Autonomous Region: a cross-sectional study]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38(4):467-471.
OBJECTIVE
To analyze the type-specific prevalence of human papillomavirus (HPV) among women aged 18-45 years from the general population in Liuzhou, Guangxi Zhuang Autonomous Region.

METHODS
Totally, 2 300 women aged 18-45 years old were enrolled in Liuzhou,from March to July, 2013.Cervical exfoliated cells were collected for liquid based cytological and HPV DNA tests. Women were referred to colposcopy exam, based on the clinical practice guideline.

RESULTS
Overall, the prevalence rates of any HPV or oncogenic HPV appeared as 22.7% (95% CI: 21. 0%-24. 4%) and 17. 3% (95% CI: 16. 0%-19. 1%), respectively in this population under study. The high-risk HPV prevalence peaked at the age groups of 18-25 and 41-45, increasing along with the severity through cytological and histological tests. Statistically significant differences between the prevalence of CIN2+ (Cervical intraepithelial neoplasia 2+) in women older than 26 years (1. 7%, 95% CI: 1. 0%-2. 4%) and 18-25 years (1. 2%, 95% CI: 0. 5%-1. 9%) of age, were not observed. Among samples diagnosed as CIN2+, positivity of HPV bivalent (16/18) and nine-valent (6/11/16/18/31/33/45/52/58) vaccine, related high risks on the types of HPV types appeared as 44. 1% and 97. 1%.

CONCLUSIONS
The age-specific HPV prevalence rates in the general women aged 18-45 in Liuzhou presented as having bimodal distribution, suggesting that the disease burden of cervical diseases in women aged 26-45 years should not be ignored.Nine-valent HPV vaccine might provide more effective prevention outcomes on cervical cancer in China.