Evaluation of chemical mutagenicity using next generation sequencing: a review.

Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews

PubMedID: 28506110

Du H, Pan B, Chen T. Evaluation of chemical mutagenicity using next generation sequencing: a review. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2017;0.
Mutations are heritable changes in the nucleotide sequence of DNA that can lead to many adverse effects. Genotoxicity assays have been used to identify chemical mutagenicity. Recently, next generation sequencing (NGS) has been used for this purpose. In this review, we present the progress in NGS application for assessing mutagenicity of chemicals, including the methods used for detecting the induced mutations, bioinformatics tools for analyzing the sequencing data, and chemicals whose mutagenicity has been evaluated using NGS. Available information suggests that NGS technology has unparalleled advantages for evaluating mutagenicity of chemicals becomes the next generation of mutagenicity tests.