Novel functions for chromatin dynamics in mRNA biogenesis beyond transcription.

Nucleus (Austin, Tex.)

PubMedID: 28816581

Dargemont C, Babour A. Novel functions for chromatin dynamics in mRNA biogenesis beyond transcription. Nucleus. 2017;0.
The first step of gene expression results in the production of mRNA ribonucleoparticles (mRNPs) that are exported to the cytoplasm via the NPC for translation into the cytoplasm. During this process, the mRNA molecule synthesized by RNA polymerase II (Pol II) undergoes extensive maturation, folding and packaging events that are intimately coupled to its synthesis. All these events take place in a chromatin context and it is therefore not surprising that a growing number of studies recently reported specific contributions of chromatin dynamics to various steps of mRNP biogenesis. In this extra view, we replace our recent findings highlighting the contribution of the yeast chromatin remodeling complex ISW1 to nuclear mRNA quality control in the context of the recent literature.