Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish population.

Cellular and molecular biology (Noisy-le-Grand, France)

PubMedID: 28886321

Attar R, Yilmaz SG, Çakmakoglu B, Duman S, Yildirim G, Görmüs U, Isbir T. Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish population. Cell Mol Biol (Noisy-le-grand). 2017;63(8):100-103.
The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G)  in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52). There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0. 049; x2=6. 042). AA carriers were significantly higher in the control group (p=0. 014) whereas AG genotype and G allele carriers were significantly higher in the ovarian cancer group (p=0. 029, p=0. 014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer.