Anti-arthritic and immunosuppressive activities of substituted triterpenoidal candidates.

International journal of biological macromolecules

PubMedID: 23603083

Alanazi AM, Al-Omar MA, Abdulla MM, Amr Ael-G. Anti-arthritic and immunosuppressive activities of substituted triterpenoidal candidates. Int J Biol Macromol. 2013;58245-52.
We herein report the anti-arthritic and immunosuppressive activities of some synthesized substituted terpenoidal structure. Forty-four triterpenoid derivatives 1-21 containing a carboxylic, ester, amide and ketone groups attached to a triterpene moiety were conveniently synthesized and screened for their anti-arthritic and immunosuppressive activities. Synthetic triterpenoidal structures linked to a different function groups seem to be a promising approach in the search for novel leads for potent anti-arthritic and immunosuppressive agents. The detailed synthetic pathways of obtained compounds and anti-arthritic and immunosuppressive activities were reported.