Complement activation by anti-GQ1b antibodies in Fisher syndrome and its variants.

Journal of neuroimmunology

PubMedID: 23566402

Yuki N, Hirata K. Complement activation by anti-GQ1b antibodies in Fisher syndrome and its variants. J Neuroimmunol. 2013;258(1-2):100-1.
IgG anti-GQ1b antibodies are associated with Fisher syndrome (FS) as well as with its more and less extensive variants, Bickerstaff brainstem encephalitis and acute ophthalmoparesis. Passive transfer experiments provide evidence that anti-ganglioside antibodies and complement are pathogenic in the development of FS. In the current in vitro study, we could not demonstrate the association of complement activation with disease extension.