Peritoneal mast cell stabilization potential of Pothos scandens L.

Indian journal of pharmacology

PubMedID: 23542883

Gupta S, Duraiswamy B, Satishkumar MN. Peritoneal mast cell stabilization potential of Pothos scandens L. Indian J Pharmacol. 2013;45(1):83-6.
OBJECTIVE
To investigate the peritoneal mast cell stabilization activity of Pothos scandens extracts.

MATERIALS AND METHODS
Pothos scandens L. (family- Araceae) aerial part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of P. scandens were evaluated for stabilization of mast cell in rat allergic models. The extract of P. scandens ethanolic, 50% aqueous ethanolic and aqueous (1, 10 and 100 µg/ml) was studied for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80.

RESULT
Preliminary phytochemical analysis revealed the presence of carbohydrates, fixed oil, proteins, alkaloids, glycosides, flavonoids and phenolic compounds. The ethanolic, 50% aqueous ethanolic and aqueous extracts of P. scandens L. showed dose dependent increase in the number of intact cells when compare with C48/80 at the concentration of 10 and 100 µg/ml. It virtues further work towards the isolation of phytoconstituents from this plant.

CONCLUSION
This finding provides evidence that the P. scandens L. inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation. P. scandens has a potential as allergic anti- asthmatic agent.