Recognition of goblet cells upon endocytoscopy indicates the presence of gastric intestinal metaplasia.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

PubMedID: 23551261

Chiu PW, Ng EK, To KF, Teoh AY, Lam CC, Chan FK, Sung JJ, Lau JY. Recognition of goblet cells upon endocytoscopy indicates the presence of gastric intestinal metaplasia. Dig Endosc. 2013;.
BACKGROUND: Gastric intestinal metaplasia (IM) is considered precancerous and is difficult to differentiate upon endoscopy. Endocytoscopy enables observation at a cellular level for focused biopsy. The present study examined the use of endocytoscopy for recognition of gastric IM. PATIENTS AND METHODS: Patients with a history of gastric IM were recruited. We first carried out narrow band imaging (NBI) endoscopy to look for suspicious areas of gastric IM. A prototype endocytoscope with a magnification of 450× was used to re-examine these areas. Areas examined were biopsied for histological comparison. Presence of goblet cells was considered as representative of IM upon endocytoscopy. RESULTS: Twenty patients were recruited with NBI demonstrating 102 suspicious lesions of gastric IM. Mean age of patients was 53.9?±?7.6 years. Upon histology, 72 biopsies were confirmed as gastric IM, 15 showed IM and low-grade dysplasia, whereas 15were diagnosed as chronic gastritis. Endocytoscopy image quality was significantly better for areas of IM as compared to gastritis (P?