Zinc deficiency enhances the induction of micronuclei and 8-hydroxy-2'-deoxyguanosine via superoxide radical in bone marrow of zinc-deficient rats.

Biological trace element research

PubMedID: 23712836

Kawasaki I, Suzuki Y, Yanagisawa H. Zinc deficiency enhances the induction of micronuclei and 8-hydroxy-2'-deoxyguanosine via superoxide radical in bone marrow of zinc-deficient rats. Biol Trace Elem Res. 2013;154(1):120-6.
The aim of the present study was to examine whether zinc (Zn) deficiency augmented the frequency of micronuclei, an indicator of chromosome aberration, and the induction of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of cellular DNA damage derived from oxidative stress, in rat bone marrow cells or not. Both the frequency of micronuclei and the induction of 8-OHdG were significantly increased in rats fed with a Zn-deficient versus a standard diet for 6 weeks (p?