Diffusion-weighted MR imaging of salivary glands with gustatory stimulation: comparison before and after radiotherapy.

Acta radiologica (Stockholm, Sweden : 1987)

PubMedID: 23821773

Zhang Y, Ou D, Gu Y, He X, Peng W, Mao J, Yue L, Shen X. Diffusion-weighted MR imaging of salivary glands with gustatory stimulation: comparison before and after radiotherapy. Acta Radiol. 2013;.
BACKGROUND
Xerostomia is the most prominent complication in patients with head and neck carcinoma after radiotherapy (RT). Diffusion-weighted magnetic resonance imaging (DWI) with gustatory stimulation may contribute to the evaluation of salivary gland function.

PURPOSE
To investigate the value of DWI for quantifying physiological changes of the parotid gland during gustatory stimulation in patients before and after RT.

MATERIAL AND METHODS
Magnetic resonance imaging (MRI) was performed in 28 consecutive patients with nasopharyngeal carcinoma before and after RT and clinical xerostomia was also assessed. A DWI sequence was performed once at rest and continually repeated seven times during stimulation with ascorbic acid. Apparent diffusion coefficient (ADC) maps for parotid glands at different time points and the range of increase with stimulation were calculated. Paired two-tailed Student t tests were used to compare the ADC values before and after stimulation, and before and after RT.

RESULTS
Before RT, the ADC showed an initial increase (P?
CONCLUSION
DWI combined with gustatory stimulation seems to display the physiological changes of the parotid gland following RT and may be a potential tool for non-invasively assessing salivary gland function.