Just a Trim, Please: Refining ER Degradation through Deubiquitination.

Cell

PubMedID: 23890819

Brodsky JL. Just a Trim, Please: Refining ER Degradation through Deubiquitination. Cell. 2013;154(3):479-81.
ER-associated degradation clears the secretory pathway of misfolded proteins and mediates the regulated degradation of some ER resident proteins. Only a minor increase in the interaction between a protein and a ubiquitin ligase is sufficient to signal substrate degradation. Zhang et al. have identified deubiquitination as a signal amplifier.