Lower cortical porosity and higher tissue mineral density in Chinese-American versus white women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

PubMedID: 23913668

Boutroy S, Walker MD, Liu XS, McMahon DJ, Liu G, Guo XE, Bilezikian JP. Lower cortical porosity and higher tissue mineral density in Chinese-American versus white women. J Bone Miner Res. 2013;.
INTRODUCTION
Asian women have lower rates of hip and forearm fractures compared to other racial groups despite lower areal BMD. We have demonstrated microarchitectural differences, including greater cortical thickness (Ct.Th) and cortical volumetric BMD (Ct.BMD), in Chinese-American versus white women. Yet, it is not known whether greater Ct.BMD in Chinese-American women is due to greater tissue mineral density (TMD) or reduced cortical porosity (Ct.Po).

METHODS
Using an advanced segmentation algorithm based on high-resolution peripheral quantitative computed tomography images, we tested the hypothesis that Chinese-American women have better cortical skeletal integrity due to lower Ct.Po and higher Ct.TMD compared with white women. 78 Chinese-American women (49 pre- and 29 postmenopausal) and 114 white women (46 pre- and 68 postmenopausal) were studied.

RESULTS
Premenopausal Chinese-American vs. white women had greater Ct.Th, Ct.BMD and Ct.TMD at both the radius and tibia; and decreased Ct.Po (p?
CONCLUSION
In summary, both reduced Ct.Po and greater Ct.TMD explain higher Ct.BMD in Chinese-American versus white women. Thicker and preserved cortical bone structure in Chinese-American women may contribute to greater resistance to fracture compared to white women.