Extrusion-spheronisation of microcrystalline cellulose pastes using a non-aqueous liquid binder.

International journal of pharmaceutics

PubMedID: 20123008

Mascia S, Seiler C, Fitzpatrick S, Wilson DI. Extrusion-spheronisation of microcrystalline cellulose pastes using a non-aqueous liquid binder. Int J Pharm. 2010;389(1-2):1-9.
An experimental investigation of extrusion-spheronisation (E-S) of a novel microcrystalline cellulose (MCC) formulation, comprising dimethyl sulfoxide (DMSO) as the granulating liquid, is reported. The extrusion-spheronisation performance of DMSO/MCC pastes is compared to that of similar water/MCC formulations and their rheological behaviours similarly assessed using lubricated squeeze flow. A case study involving water, DMSO and anhydrous ethanol yields important information regarding the physico-chemical properties necessary for solvents to be suitable for the extrusion of MCC.