Increased interleukin-18 expression in nonrheumatic aortic valve stenosis.

International journal of cardiology

PubMedID: 19217172

Naito Y, Tsujino T, Wakabayashi K, Matsumoto M, Ohyanagi M, Mitsuno M, Miyamoto Y, Hao H, Hirota S, Okamura H, Masuyama T. Increased interleukin-18 expression in nonrheumatic aortic valve stenosis. Int J Cardiol. 2010;144(2):260-3.
BACKGROUND
It is unknown whether interleukin-18 (IL-18) participates in the pathophysiology of nonrheumatic aortic stenosis (NR-AS).

METHODS
We examined IL-18 expression in human NR-AS valves by immunohistochemistry and Western blot analysis.

RESULTS
Immunohistochemistry revealed that NR-AS valves showed increased IL-18 expression compared with controls. IL-18 receptor was also expressed in NR-AS valves. Western blot analysis showed that IL-18 was expressed as an active form in NR-AS valves. Furthermore, increased IL-18 expression was correlated with the advanced clinical severity of NR-AS.

CONCLUSIONS
IL-18 was expressed in the aortic valves and up-regulated in NR-AS valves. IL-18 may contribute to the pathophysiology of NR-AS.