Lab-in-a-tube: detection of individual mouse cells for analysis in flexible split-wall microtube resonator sensors.

Nano letters

PubMedID: 21105718

Smith EJ, Schulze S, Kiravittaya S, Mei Y, Sanchez S, Schmidt OG. Lab-in-a-tube: detection of individual mouse cells for analysis in flexible split-wall microtube resonator sensors. Nano Lett. 2011;11(10):4037-42.
We report a method for the precise capturing of embryonic fibroblast mouse cells into rolled-up microtube resonators. The microtubes contain a nanometer-sized gap in their wall which defines a new type of optofluidic sensor, i.e., a flexible split-wall microtube resonator sensor, employed as a label-free fully integrative detection tool for individual cells. The sensor action works through peak sharpening and spectral shifts of whispering gallery modes within the microresonators under light illumination.