[Prodrug technology in the development of medicinal agents].

Duodecim; laaketieteellinen aikakauskirja

PubMedID: 21438349

Peura L, Malmioja K, Rautio J. [Prodrug technology in the development of medicinal agents]. Duodecim. 2011;127(3):263-72.
Medicinal agents acetosalicylic acid, lansoprazole, simvastatin, clopidogrel and oseltamivir are known prodrugs. Prodrugs are pharmacologically inactive medicine molecules, from which the active drug is released in the body through a chemical or enzymatic reaction. This mechanism can be used to solve pharmaceutical and pharmacokinetic problems restricting the use of medicinal agents, without altering the pharmacological effects of the agent that ends up in the site of action. Of the medicinal agents currently on the market, as many as one out of ten is a prodrug.