Expression of VLA-4 molecule in PBMC from patients with hemorrhagic fever with renal syndrome.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

PubMedID: 21298552

Xie M, Dong Y, He L, Ren H, Ji Y, Lv S. Expression of VLA-4 molecule in PBMC from patients with hemorrhagic fever with renal syndrome. Inflamm Res. 2011;60(7):613-7.
OBJECTIVE AND DESIGN
The very late antigen-4 (VLA-4) bound to vascular cell adhesion molecule-1 could provide co-stimulatory signals for the activation of T lymphocytes, and these adhesion molecules play key roles in leukocyte adherence and propagation of inflammatory responses. We examined the levels of VLA-4 in the peripheral blood mononuclear cells (PBMC) of patients with hemorrhagic fever with renal syndrome (HFRS).

MATERIALS AND METHODS
The levels of VLA-4 in PBMC samples collected from 53 patients by immunohistochemical staining were detected.

RESULTS
The expression of VLA-4 in PBMC of HFRS patients at different stages were significantly higher than those in normal controls (P < 0.05), except recovery stage (P > 0.05). The expression of VLA-4 in PBMC of HFRS patients at different types were significantly higher than those in healthy controls (P < 0.05). The levels of VLA-4 in patients with HFRS were positively correlated with serum levels of blood urea nitrogen (BUN) and creatinine (Cr).

CONCLUSIONS
VLA-4 might play an important role in the immunopathological lesions of HFRS. We found that VLA-4 levels were closely correlated to the severity of the HFRS and the degree of kidney damage.