Profiling B-type natriuretic peptide in a stable heart failure population: a valuable adjunct to care.

Irish journal of medical science

PubMedID: 21369749

Jan A, Murphy NF, O'Loughlin C, Ledwidge M, McDonald K. Profiling B-type natriuretic peptide in a stable heart failure population: a valuable adjunct to care. Ir J Med Sci. 2011;180(2):355-62.
AIM
To examine the prognostic importance of absolute values and change in values of BNP in patients with stable heart failure (HF).

METHODS
Five-hundred and fifty-nine patients attending a disease management programme were categorized into tertiles of BNP (group 1; = 95 pg/ml, group 2; 96-249 pg/ml and group 3; = 250 pg/ml). A change in BNP between two stable visits was recorded. Patients were followed up for 1 year for death and a composite morbidity measure of HF hospitalization, all-cause hospitalization, unscheduled visits for clinical deterioration(UC) of HF using survival analysis.

RESULTS
The risk of the combined morbidity outcome increased with increasing tertiles of BNP (Log rank = 17.8 (2), p < 0.001). Furthermore, a 50 and 25% increase in BNP predicted morbidity in stable HF patients with an initial BNP > 200 pg/ml (p = 0.02) and > 450 pg/ml (p = 0.03), respectively.

CONCLUSION
In a stable community HF population, an elevated BNP or an increase in BNP predicts an adverse prognosis thereby potentially identifying a population in need of closer clinical follow-up.