Health related quality of life among patients with chronic graft-versus-host disease in China.

Chinese medical journal

PubMedID: 23981610

Mo XD, Xu LP, Liu DH, Chen YH, Zhang XH, Chen H, Han W, Wang Y, Wang FR, Wang JZ, Liu KY, Huang XJ. Health related quality of life among patients with chronic graft-versus-host disease in China. Chin Med J. 2013;126(16):3048-52.
BACKGROUND
Chronic graft-versus-host disease (GVHD), the commonest long-term complication after allogeneic hematopoietic stem cell transplantation (HSCT), has a negative impact on patients' health related quality of life (HRQoL). This study was designed to investigate the HRQoL in patients with chronic GVHD in China.

METHODS
Two hundred and sixty-four patients with chronic GVHD who were = 24 months post-HSCT and had been in continuous complete remission since HSCT were enrolled in this retrospective study. HRQoL was evaluated using an SF-36 questionnaire. Multivariate analysis was used to identify the factors that affect HRQoL in patients with chronic GVHD.

RESULTS
HRQoL in patients categorized as having mild and moderate chronic GVHD was significantly better than in those in the severe category. In the moderate chronic GVHD category, markedly poorer HRQoL was observed in patients with both multiple organ involvement and more severe organ impairment than in those without these factors. According to multivariate analysis, chronic GVHD severity had the greatest significant negative impact on patients' HRQoL; whereas being female was associated with a negative impact on psychological health.

CONCLUSION
Chronic GVHD severity strongly correlates with negative impacts on patients' HRQoL.