[Comparative efficacy of albendazole and mebendazole oily suspensions in albino mice with experimental larval alveococcosis].

Meditsinskaia parazitologiia i parazitarnye bolezni

PubMedID: 24003516

Kovalenko FP, Kukhaleva IV, Shkoliar NA, Legon'kov IuA. [Comparative efficacy of albendazole and mebendazole oily suspensions in albino mice with experimental larval alveococcosis]. Med Parazitol (Mosk). 2013;(2):17-20.
The comparative efficacy of albendazole and mebendazole oily suspensions (AOS and MOS) was studied in an experimental model of experimental larval alveococcosis in albino mice. The animals were intragastrically injected with the agents once daily for 40 days on day 35 after intraperitoneal inoculation with E. multilocularis acephalocysts. They were dissected 29 days after treatment termination (103 days following inoculation) and the rate of infestation and viability and the degree of maturity of developed alveococcosis larvocysts (AL) were determined. The AOS and MOS efficiency estimated by the mean mass of AL per animal was 83.3 and 98.1%, respectively; whereas the similar indicator calculated by one largest AL weight per animal found among all the animals in the compared groups was equal to 57.7 and 96.9%, respectively. Under the equal conditions of solubilization in vegetable oil, the biological activity and bioavailability of mebendazole were shown to increase to a much greater extent than those of albendazole. The findings suggest that the use of mebendazole is promising for designing new vegetable oil-based formulations of the agent.