One-pot cross double-Mannich reaction of acetaldehyde catalyzed by a binaphthyl-based amino sulfonamide.

Chemical communications (Cambridge, England)

PubMedID: 23282574

Kano T, Sakamoto R, Yamaguchi Y, Itoh K, Maruoka K. One-pot cross double-Mannich reaction of acetaldehyde catalyzed by a binaphthyl-based amino sulfonamide. Chem Commun (Camb). 2013;49(11):1118-20.
A one-pot cross double-Mannich reaction of acetaldehyde was developed, and densely functionalized 1,3-diamines were obtained as a single stereoisomer by use of axially chiral amino sulfonamide (S)-1 as catalyst. Using this catalyst, the one-pot Mannich reaction-aminoxylation was also realized.