Effects of polymorphisms in translesion DNA synthesis genes on lung cancer risk and prognosis in Chinese men.

Cancer epidemiology

PubMedID: 24012694

Xu HL, Gao XR, Zhang W, Cheng JR, Tan YT, Zheng W, Shu XO, Xiang YB. Effects of polymorphisms in translesion DNA synthesis genes on lung cancer risk and prognosis in Chinese men. Cancer Epidemiol. 2013;.
PURPOSE
Translesion DNA synthesis (TLS) plays an important role in promoting replication through DNA lesions. Genetic polymorphisms in TLS genes may have potential roles in lung cancer development in humans.

METHODS
We evaluated the association between genetic variants in six TLS genes and the risk and survival of lung cancer in a case-control study in China. Included in the study are 224 lung cancer patients and 448 healthy controls.

RESULTS
Carriers of the G allele of POL? rs5744724 had significantly reduced risk of lung cancer (odds ratio (OR)=0.62, 95% confidence interval (CI): 0.44-0.89), comparing with those carrying the C allele, and the AA genotype of PCNA rs25406 was also associated with significantly decreased cancer risk compared with the major homozygote alleles (OR=0.47, 95% CI: 0.25-0.86). Haplotype analysis showed that subjects with the POL? C-G (rs5744533-rs5744724) haplotype had decreased risk of lung cancer (OR=0.69, 95% CI: 0.49-0.98), comparing with those carrying the C-C haplotype. Besides, the heterozygote of REV1 rs3087386 and rs3792136 were independent prognostic factors for lung cancer survival with hazard radio (HR) 1.54 (95% CI: 1.12-2.12) and 1.44 (95% CI: 1.06-1.97) respectively.

CONCLUSIONS
Our findings suggested that genetic variants in POL? and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men.