Preparation and characterization of antioxidant nanospheres from multiple alpha-lipoic acid-containing compounds.

Bioorganic & medicinal chemistry letters

PubMedID: 19231184

Lee BS, Yuan X, Xu Q, McLafferty FS, Petersen BA, Collette JC, Black KL, Yu JS. Preparation and characterization of antioxidant nanospheres from multiple alpha-lipoic acid-containing compounds. Bioorg Med Chem Lett. 2009;19(6):1678-81.
The purpose of this study was to prepare and characterize antioxidant nanospheres composed of multiple alpha-lipoic acid-containing compounds (mALAs). It was found that the nanospheres were remarkably stable under physiologic conditions, maintained the antioxidant property of alpha-lipoic acid, and could be destabilized oxidatively and enzymatically. The preparations were simple and highly reproducible providing a new strategy for the development of nanometer-sized antioxidant biomaterials. The nanospheres may find applications as antioxidant therapeutics and oxidation-responsive antioxidant nanocontainers in drug delivery for pathological conditions characterized by oxidative stress including cancer and neurodegenerative diseases.