Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines.

European journal of medicinal chemistry

PubMedID: 19285757

Rashad AE, Hegab MI, Abdel-Megeid RE, Fathalla N, Abdel-Megeid FM. Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines. Eur J Med Chem. 2009;44(8):3285-92.
5-Amino-1-substituted-1H-pyrazole-4-carbonitrile derivative 1 was used as a precursor for preparation of some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives 2-10. Furthermore, the preparation of sugar hydrazone derivatives 11a,b, 12a,b and their annelated C-nucleosides 13a,b was described. Some of the prepared products revealed promising antiviral activity against herpes simplex virus type-1 (HSV-1) in comparison to Acyclovir as a control.