Improving quality of magnetic resonance cholangiopancreaticography: esomeprazole versus ranitidine.

Hepato-gastroenterology

PubMedID: 19579584

Hadidy A, Haroun A, Mahafza W, Barbarawi T, Arafeh F, Shannak M. Improving quality of magnetic resonance cholangiopancreaticography: esomeprazole versus ranitidine. Hepatogastroenterology. 2009;56(90):290-3.
BACKGROUND/AIMS
The aim of this study was to evaluate the effect of Ranitidine and Esomeprazole on the pancreatico-biliary tree and to define their role in improving visualization quality on magnetic resonance cholangiopancreaticography images.

METHODOLOGY
Magnetic resonance cholangiopancreaticography was done on 70 volunteers before and after using ranitidine for half of them and esomeprazole for the other half of the group. The images were evaluated for contrast effect (signal from stomach and duodenum), and image effect (conspicuousness) at various segments of pancreaticobiliary tree.

RESULTS
Improvement of Contrast effect on stomach and duodenum in Esomeprazole group was 72.5% and in Ranitidine group was 28.6%. While image effect of pancreatic duct for Esomeprazole was 60% and for Ranitidine was 17.1%, and their statistical results were in concordance with p value (< 0.01), but the image effect of the biliary tree didn't show any significant improvement or difference between imaging and statistical results.

CONCLUSION
Esomeprazole is superior to Ranitidine in improving the quality of Magnetic Resonance Cholangiopancreaticography images especially the contrast effect of duodenum and stomach and image effect of pancreatic duct.