Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients.

Journal of the neurological sciences

PubMedID: 19303604

Bednarska-Makaruk M, Rodo M, Graban A, Lojkowska W, Bochynska A, Ryglewicz D, Wehr H. Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients. J Neurol Sci. 2009;283(1-2):137-8.
In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of epsilon2 allele and less frequent in the carriers of epsilon4 allele.