Influence of gastrointestinal digestion and edible plants combination on oral bioavailability of triterpene saponins, using biomimetic digestion and absorption system and determination by HPLC.

Journal of agricultural and food chemistry

PubMedID: 24099303

Li SX, Mu Y, Zheng FY. Influence of gastrointestinal digestion and edible plants combination on oral bioavailability of triterpene saponins, using biomimetic digestion and absorption system and determination by HPLC. J Agric Food Chem. 2013;.
Saponins have many biological activities, but their overload could cause toxicity to human body. Bionic gastrointestinal digestion and monolayer liposome extraction were used for oral bioavailability assessment of triterpene saponins (notoginsenoside R1, ginsenoside Rb1 and Rd1) in edible herb (San-Chi) and its compound herbal medicine (Pien Tze Huang, PZH). The concentrations of affinity-monolayer liposome saponins in the chyme were determined by HPLC and used for oral bioavailability assessment. With the digestion of San-Chi and PZH from stomach to intestine, the release of saponins in their chyme was increased. The intestinal absorption ratios of N-R1, G-Rb1, G-Rd1, and total saponins from San-Chi were 86.57%, 18.56%, 73.30%, and 40.20%, which were more than those from PZH (i.e., 19.56%, 10.11%, 30.11%, and 16.08%). The oral bioavailability of saponins was controlled by saponins species, gastrointestinal digestion, and edible plants combination.