Continuous exposure to 60?Hz magnetic fields induces duration- and dose-dependent apoptosis of testicular germ cells.

Bioelectromagnetics

PubMedID: 24123080

Kim HS, Park BJ, Jang HJ, Ipper NS, Kim SH, Kim YJ, Jeon SH, Lee KS, Lee SK, Kim N, Ju YJ, Gimm YM, Kim YW. Continuous exposure to 60?Hz magnetic fields induces duration- and dose-dependent apoptosis of testicular germ cells. Bioelectromagnetics. 2013;.
To evaluate duration- and dose-dependent effects of continuous exposure to a 60?Hz magnetic field (MF) on the testes in mice, BALB/c male mice were exposed to a 60?Hz MF at 100?µT for 24?h a day for 2, 4, 6, or 8 weeks, and at 2, 20, or 200?µT for 24?h a day for 8 weeks. Any exposures to MF did not significantly affect body or testicular masses. However, the apoptotic cells among testicular germ cells were increased duration-dependent at exposures of 100?µT for 6 and 8 weeks and dose-dependent at exposures of 20 and 200?µT for 8 weeks. The number of sperm in epididymis and the diameter of seminiferous tubule decreased in mice exposed to 100 and 200?µT for 8 weeks, respectively. To induce the apoptosis of testicular germ cell in mice, the minimum dose is 20?µT at continuous exposure to a 60?Hz MF for 8 weeks and the minimum duration is 6 weeks at continuous exposure of 100?µT. Taken together, these results suggest that continuous exposure to a 60?Hz MF might affect, duration- and dose-dependent biological processes including apoptotic cell death and spermatogenesis in the male reproductive system of mice. Bioelectromagnetics © 2013 Wiley Periodicals, Inc.