?-Amino acid mutated a-coiled coils as mild thermal triggers for liposome delivery.

Chemical communications (Cambridge, England)

PubMedID: 24141809

Jadhav SV, Singh SK, Reja RM, Gopi HN. ?-Amino acid mutated a-coiled coils as mild thermal triggers for liposome delivery. Chem Commun (Camb). 2013;49(94):11065-7.
The stability and compatibility of designed coiled coil peptides towards the selective incorporation of ?(4)-amino acids at the hydrophobic positions of the heptad repeat are studied. Investigations reveal that the low thermal denaturation temperature of ?(4)-residue mutated coiled coils can be utilized as a mild hyperthermia trigger in liposomes.