The promise of riboswitches as potential antibacterial drug targets.

International journal of medical microbiology : IJMM

PubMedID: 24140145

Lünse CE, Schüller A, Mayer G. The promise of riboswitches as potential antibacterial drug targets. Int J Med Microbiol. 2013;.
Riboswitches represent promising novel RNA structures for developing compounds that artificially regulate gene expression and, thus, bacterial growth. The past years have seen increasing efforts to identify metabolite-analogues which act on riboswitches and which reveal antibacterial activity. Here, we summarize the current inventory of riboswitch-targeting compounds, their characteristics and antibacterial potential.