Polymer-peptide block copolymers - an overview and assessment of synthesis methods.

Macromolecular bioscience

PubMedID: 19551761

Robson Marsden H, Kros A. Polymer-peptide block copolymers - an overview and assessment of synthesis methods. Macromol Biosci. 2009;9(10):939-51.
Incorporating peptide blocks into block copolymers opens up new realms of bioactive or smart materials. Because there are such a variety of peptides, polymers, and hybrid architectures that can be imagined, there are many different routes available for the synthesis of these chimera molecules. This review summarizes the contemporary strategies in combining synthesis techniques to create well-defined peptide-polymer hybrids that retain the vital aspects of each disparate block. Living polymerization can be united with the molecular-level control afforded by peptide blocks to yield block copolymers that not only have precisely defined primary structures, but that also interact with other (bio)molecules in a well defined manner.