Making the most of what you've got: optimizing residual OXPHOS function in mitochondrial diseases.

EMBO molecular medicine

PubMedID: 20049740

Moraes CT. Making the most of what you've got: optimizing residual OXPHOS function in mitochondrial diseases. EMBO Mol Med. 2009;1(8-9):357-9.
Patients affected by mitochondrial OXPHOS disorders are still faced with a grim lack of therapeutic options. In this Closeup, Carlos Moraes revisits the recent data by Giovanni Manfredi on PKA's functions in the mitochondria and now its modulation can improve respiration and ATP production in COX-defective cells.