Glomerular disease: sugars and immune complex formation in IgA nephropathy.

Nature reviews. Nephrology

PubMedID: 19855421

Barratt J, Eitner F. Glomerular disease: sugars and immune complex formation in IgA nephropathy. Nat Rev Nephrol. 2009;5(11):612-4.
In vitro evidence suggests that immune complex formation in IgA nephropathy is determined by the sugar content of the IgA1 hinge region. Absence of galactose residues in this region renders the IgA1 molecule immunogenic.