Smart nanofibers with a photoresponsive surface for controlled release.

ACS applied materials & interfaces

PubMedID: 20356110

Fu GD, Xu LQ, Yao F, Li GL, Kang ET. Smart nanofibers with a photoresponsive surface for controlled release. ACS Appl Mater Interfaces. 2009;1(11):2424-7.
A novel photocontrolled "ON-OFF" release system for the alpha-cyclodextrin-5-fluorouracial (alpha-CD-5FU) prodrug, based on host-guest interaction on the photoresponsive and cross-linked nanofiber surface, was demonstrated. The nanofibers with a stimuli-responsive surface were electrospun from the block copolymer prepared via controlled radical polymerization, followed by surface modification via "Click Chemistry", and loading of the prodrug via host-guest interaction.