[Synthesis and antitumor activities of triazacyclodecane and its platinum (II) complex].

Yao xue xue bao = Acta pharmaceutica Sinica

PubMedID: 18717336

Zhou SS, Zhang QY, Qin K, Lu CH, Xie FX. [Synthesis and antitumor activities of triazacyclodecane and its platinum (II) complex]. Yao Xue Xue Bao. 2008;43(5):490-4.
To search for potential antitumor drugs with potent efficiency and low toxicity, a novel 1,4,7-triazacyclodecane and its platinum (II) complex were synthesized. These compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, MS spectra, thermoanalysis and conductivity measurement. Antitumor activity study indicated these compounds had strong antitumor activity in vitro to some extent. Inhibition of human liver tumor of CA was examined by antitumor rate and growth rate, complex C showed inhibition activity on transplanting-tumor growth of CA, 12 mg x kg(-1) was as potent as cisplatin, its ID50 was 853.6 mg x kg(-1).