Simplified Deoxypropionate Acyl Chains for Mycobacterium tuberculosis Sulfoglycolipid Analogues: Chain Length is Essential for High Antigenicity.

Chembiochem : a European journal of chemical biology

PubMedID: 24174158

Gau B, Lemétais A, Lepore M, Garcia-Alles LF, Bourdreux Y, Mori L, Gilleron M, De Libero G, Puzo G, Beau JM, Prandi J. Simplified Deoxypropionate Acyl Chains for Mycobacterium tuberculosis Sulfoglycolipid Analogues: Chain Length is Essential for High Antigenicity. Chembiochem. 2013;.
The longer, the better: Increasing the lengths of the 1,3-methyl-branched fatty acyl chain units in mycobacterial diacylated sulfoglycolipid (Acyl2 SGL) analogues led to dramatic improvements in their antigenic properties and gave products more potent than the natural antigen Acyl2 SGLs.