The effect of HESA-A on psoriasis vulgaris.

Journal of drugs in dermatology : JDD

PubMedID: 18561587

Ahmadi A, Barikbin B, Naseri M, Mohagheghi M. The effect of HESA-A on psoriasis vulgaris. J Drugs Dermatol. 2008;7(6):559-61.
BACKGROUND
Psoriasis vulgaris is one of the most common chronic skin disorders without any curative treatment. The aim of this study was to investigate the efficacy and safety of HESA-A in the treatment of psoriasis.

METHODS
In a randomized, double-blind clinical trial, 28 patients (11 male, 17 female) with chronic plaque-type psoriasis were randomly assigned to treatment and placebo groups. Patients in treatment group received HESA-A tablet 25 mg/kg twice a day orally and control group received placebo with the same method for 6 months and were followed clinically during the study.

RESULTS
At the end of study, in the treatment group psoriatic plaques were absent (no evidence of psoriasis or complete remission) in 9 cases (64.2%) and was very mild (controlled, but not entirely cleared) in 5 cases (35.8%). Disease relief was observed in 10 (71.4%) patients after 4 months, in 2 cases (14.3%) after 5 months and in 2 (14.3%) other patients after 6 months while none of the controls showed disease improvement.

CONCLUSION
This study showed rapid and good efficacy and safety of HESA-A in the treatment of plaque-type psoriasis.