Synthesis and surface activity of diether-linked phosphoglycerols: potential applications for exogenous lung surfactants.

Bioorganic & medicinal chemistry letters

PubMedID: 17055273

Wang Z, Wang Z, Davy JA, Schwan AL, Notter RH. Synthesis and surface activity of diether-linked phosphoglycerols: potential applications for exogenous lung surfactants. Bioorg Med Chem Lett. 2007;17(1):113-7.
The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs were measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants.