[Comparison of transdermal permeation in vitro of lidocaine tincture and microemulsion].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

PubMedID: 17545055

Huang L, Chen ZL, Li GF, Zhu XL, Liu C. [Comparison of transdermal permeation in vitro of lidocaine tincture and microemulsion]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27(4):541-2.
OBJECTIVE
To compare lidocaine tincture and microemulsion for their transdermal permeation.

METHODS
The experimental model for percutaneous administration of lidocaine preparations in vitro was prepared using modified Franz diffusion cell.

RESULTS
The accumulated infiltration amount of lidocaine microemulsion in unit area was higher than that in its cream or tincture preparations.

CONCLUSION
The transdermal permeation of lidocaine microemulsion in vitro can be more efficient than that of the tincture preparation, and the permeation is linearly dependent on the dose administered within a certain range.