[Is there an association of uric acid level with preclinical target organ damage in moderate- and high-risk hypertensive patients?].

Terapevticheskii arkhiv

PubMedID: 24261230

Dmitriev VA, Oshchepkova EV, Titov BN, Rogoza AN, Saidova MA, Bolotova MN, Gushchina OV, Polevaia TY. [Is there an association of uric acid level with preclinical target organ damage in moderate- and high-risk hypertensive patients?]. Ter Arkh. 2013;85(9):52-7.
AIM
To assess an association of uric acid level with preclinical target organ damage in patients with hypertensive disease (HD).

SUBJECTS AND METHODS
The trial enrolled 100 patients (63 men and 37 women) with Stage I-II HD at moderate and high risk for cardiovascular events (CVEs). The mean age of the patients was 44.9 +/- 1.3 years. Their medical history showed that the duration of hypertension averaged 4.4 +/- 0.3 years. The average daily level of systolic blood pressure (BP) was 138.1 +/- 1.4 mm Hg and that of diastolic BP was 84.3 +/- 1.1 mm Hg.

RESULTS
The entire patient group showed a positive correlation between C-reactive protein (CRP) and serum uric acid (SUA) (r = 0.27; p < 0.01), suggesting that the nonspecific inflammatory processes were associated with uric acid levels in patients with HD. An intragroup analysis also revealed a relationship between CRP and SUA levels in the hypertensive patients at high risk for CVEs (r = 0.43; p = 0.01); this relationship was not found in those at their low risk. The hypertensive patients were ascertained to have elevated CRP levels and microalbuminuria, hyperuricosuria, and glomerular hyperfiltration when they had a SUA level >319 micromol/l.

CONCLUSION
It can be assumed that the SUA level >319 micromol/l triggers the activation of nonspecific inflammatory processes, which in turn affects renal microvessels.