[Genetic mechanisms in the hereditary predisposition to colorectal cancer].

Anales del sistema sanitario de Navarra

PubMedID: 16670730

Alonso A, Moreno S, Valiente A, Artigas M, Pérez-Juana A, Ramos Arroyo MA. [Genetic mechanisms in the hereditary predisposition to colorectal cancer]. An Sist Sanit Navar. 2006;29(1):59-76.
A proportion of colorectal cancers shows some type of genetic predisposition that can be recognised in clinical practice. From the classical dominant inheritance pattern of familial adenomatous polyposis or hereditary non-polyposis colorectal cancer, through the recessive transmission of the MYH associated polyposis, to the new syndromes of the "serrated pathway" or low-penetrance alleles, the discovery of new genes and a deeper understanding of the mechanisms of action of already-known ones are enabling us to understand new aspects of the colorectal carcinogenesis. This is throwing a new light on some of the observed familial aggregation patterns which had remained unexplained.