[Fulminant liver failure associated with T-cell non-Hodgkin's lymphoma and hepatitis C virus: a case report].

Gastroenterologia y hepatologia

PubMedID: 17129548

Cofré P, Valera JM, Smok G, Regonessi C, Brahm J. [Fulminant liver failure associated with T-cell non-Hodgkin's lymphoma and hepatitis C virus: a case report]. Gastroenterol Hepatol. 2006;29(9):542-5.
Hematological malignancies can affect the liver, without producing severe hepatic involvement. We report the case of a 57-year-old man with hepatitis C virus infection and mild chronic hepatitis without antiviral treatment, who developed an aggressive T-cell non-Hodgkin's lymphoma confirmed by histological studies including liver, lymph nodes and bone marrow. The patient developed massive hepatic infiltration and acute liver failure. Rescue chemotherapy was administered but the patient died soon after with severe lactic acidosis. The immunopathological features of this association and the few reports of cases presenting with acute liver failure are reviewed.