Evaluation of underdosage in the external photon beam radiotherapy of glottic carcinoma: Monte Carlo study.

Radiotherapy and Oncology

PubMedID: 16360226

Spirydovich S, Papiez L, Moskvin V, Desrosiers P. Evaluation of underdosage in the external photon beam radiotherapy of glottic carcinoma: Monte Carlo study. Radiother Oncol. 2006;78(2):159-64.
PURPOSE
Underdosage in the human larynx may be the true factor behind the decrease in local control rates.

PATIENTS AND METHODS
To evaluate underdosage with Monte Carlo a CT-based geometrical model of the patient's neck (mathematical neck) was created. Dose was calculated for a pair of 6 Me V parallel-opposed photon beams modulated with 15 degree steel wedges.

RESULTS
At least 5% of volume of 3.5 cm(3) hypothetical tumor near the air wall of the larynx receives less than 86% of the maximum tumor dose. The same volume received less than 91% of the maximum tumor dose when the mathematical neck had no air cavities.

CONCLUSIONS
We conclude the significant underdosage at the air-tissue interface in the larynx occurs in traditional radiotherapy treatments, especially in the glottic part of the larynx.