Paclitaxel, cisplatin, 5-fluorouracil and radiotherapy in the management of advanced squamous cell carcinoma of the head and neck: a phase II trial.

Radiotherapy and Oncology

PubMedID: 16086909

Merlano M, Russi EG, Numico G, Colantonio I, Garrone O, Pelissero A, Granetto C, Gasco M, Di Costanzo G, Heouaine A, Vigna Taglianti R, Cipolat M. Paclitaxel, cisplatin, 5-fluorouracil and radiotherapy in the management of advanced squamous cell carcinoma of the head and neck: a phase II trial. Radiother Oncol. 2005;75(2):193-6.
Aim of the present study was to test, activity and toxicity of a rapidly alternating chemoradiation (paclitaxel based) in 31 patients with unresectable, locally advanced or recurrent after surgery, head and neck cancer. Three-year overall survival and progression-free survival were 61.4 and 73.7%, respectively. Main side effects remain a major problem.