Reticular and Myxoid Non-keratinizing Nasopharyngeal Carcinoma: An Unusual Case Mimicking a Salivary Gland Carcinoma.

Head and Neck Pathology

PubMedID: 24323539

Petersson F, Vijayadwaja D, Loh KS, Tan KB. Reticular and Myxoid Non-keratinizing Nasopharyngeal Carcinoma: An Unusual Case Mimicking a Salivary Gland Carcinoma. Head Neck Pathol. 2014;8(3):364-8.
We present a case of non-keratinizing carcinoma of the nasopharynx (NK-NPC) with an unusual histopathological pattern. The neoplastic cells were arranged in anastomosing cords embedded in a stroma which contained a significant component of alcian blue-positive myxoid substance forming a reticular pattern. These histopathological features gave an initial impression of a salivary gland-type carcinoma. On immunohistochemistry the tumor cells were strongly and diffusely positive for cytokeratins (AE1-3 and 5/6) and p63 and there was strong and diffuse nuclear positivity for Epstein-Barr virus-encoded small RNA on in situ hybridization. This case highlights the histomorphological variability of NK-NPC. Awareness of the histological spectrum of NK-NPC is important in clinical practice and this is not always adequately highlighted in currently used standard textbooks of Head and Neck Pathology.