Necrolytic acral erythema.


PubMedID: 24365000

Yost JM, Boyd KP, Patel RR, Ramachandran S, Franks AG. Necrolytic acral erythema. Dermatol Online J. 2013;19(12):20709.
Necrolytic acral erythema is a rare, cutaneous manifestation of hepatitis C virus infection that is characterized by erythematous, violaceous or dusky papules, blisters, and/or erosions in the early stages and by well-demarcated, hyperkeratotic, targetoid plaques with a peripheral rim of macular erythema, secondary lichenification and hyperpigmentation, and overlying fine micaceous or necrotic-appearing scale in the later stages. Because most topical modalities prove ineffective, treatment of the underlying viral infection or therapeutic zinc supplementation are required for clinical improvement.