Plasmacytoid dendritic cells: in search of their niche in immune responses.

Immunologic research

PubMedID: 16106060

Barchet W, Blasius A, Cella M, Colonna M. Plasmacytoid dendritic cells: in search of their niche in immune responses. Immunol Res. 2005;32(1-3):75-83.
Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing evidence that pDCs are a distinct cell type in the innate immune system. This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses.