Follow-up of adult males with chromosome 18p deletion.

European journal of medical genetics

PubMedID: 16053911

de Ravel TJ, Thiry P, Fryns JP. Follow-up of adult males with chromosome 18p deletion. Eur J Med Genet. 2005;48(2):189-93.
The 18p- syndrome has been known for over 40 years, the first report being by de Grouchy et al. [Comptes Rendus Hebdomadaires Séances l'Acad Sci 256 (1963) 1028]. Mental retardation of varying severity is the most constant feature. Over 100 cases have been reported. The eldest patients have been 50 years [Hum Genet 63 (1983) 139; Clin Genet 2 (1971) 338]. Follow-up of two adult patients, then 22 and 42 years [Ann Génét 29 (1986) 107], now 42 and 62 years of age, is reported. Further case reports are required in order to better define the evolution of adult patients with the 18p- syndrome.