Does pancuronium or cisatracurium delay the rate of arousal following remifentanil-based anesthesia?

Middle East journal of anesthesiology

PubMedID: 16381256

Baraka AS, Haroun-Bizri ST, Nawfal MF, Gerges FJ, Nasr VG. Does pancuronium or cisatracurium delay the rate of arousal following remifentanil-based anesthesia?. Middle East J Anaesthesiol. 2005;18(3):477-84.
STUDY OBJECTIVE
The present report investigates the rate of arousal following remifentanil-based anesthesia associated with the coadministration of pancuronium, which inhibits butyrylcholinesterase, or cisatracurium, which is partially metabolized by nonspecific esterases, versus vecuronium that is eliminated independently of ester hydrolysis.

DESIGN, SETTING AND PATIENTS
Sixty patients, ASA I-II, scheduled for elective abdominal surgeries were enrolled in a double-blinded prospective study. In fact, patients were equally divided into three Groups with each Group receiving remifentanil and either one of the following three muscle relaxants: pancuronium, vecuronium or cisatracurium.

MEASUREMENTS
The rate of arousal following discontinuation of anesthesia was assessed by Modified Aldrete Score. Time to eye opening on verbal command, tracheal extubation, Modified Aldrete Score >9, and time to discharge from the recovery room were recorded.

MAIN RESULTS
Time to eye opening on verbal command, tracheal extubation, Modified Aldrete Score >9, and time to discharge from the recovery room were not significantly different between the three groups.

CONCLUSION
The results suggest that recovery following remifentanil-based anesthesia is not delayed by the coadministration of pancuronium, cisatracurium versus vecuronium; and by the use of neostigmine for reversal of neuromuscular blockade.