Virulence of metallo-beta-lactamase-producing Pseudomonas aeruginosa in vitro and in vivo.

Antimicrobial agents and chemotherapy

PubMedID: 15105148

Aoki S, Hirakata Y, Kondoh A, Gotoh N, Yanagihara K, Miyazaki Y, Tomono K, Yamada Y, Kohno S, Kamihira S. Virulence of metallo-beta-lactamase-producing Pseudomonas aeruginosa in vitro and in vivo. Antimicrob Agents Chemother. 2004;48(5):1876-8.
We evaluated the virulence of Pseudomonas aeruginosa carrying bla(IMP), a metallo-beta-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia model. The presence of bla(IMP) did not practically change the virulence of the parent strain, and ciprofloxacin was effective against infection with P. aeruginosa carrying bla(IMP).